Supplementary data on virus-like particles in the brainstem of Parkinson’s disease patients and controls

In this study, we present 84 transmission electron microscopy (TEM) images of human brainstem tissue from 11 cases late onset Parkinson’s disease (PD). The tissues were fixed, embedded, sectioned, and stained for TEM application. In addition, 14 autopsy specimens 1 case poliomyelitis infection as positive controls 8 other conditions negative controls. the PD there cytoplasmic inclusion bodies consisting virus-like particles (VLP) 30 nm in diameter that associated with endoplasmic reticulum membranes. nuclei neurons VLP ranging 40 to 50 diameter. cases, similar observed which interpreted be virus particles. one was identified showed (Figure 1, controls). A Lewy body found “control” 10) suggesting an undiagnosed PD. Cytoplasmic ribosomes measuring approximately 17 control neurons.